翻訳と辞書 Words near each other ・ Thymidine kinase 1 ・ Thymidine kinase from herpesvirus ・ Thymidine monophosphate ・ Thymidine phosphorylase ・ Thymidine triphosphate ・ Thymidine-triphosphatase ・ Thymidylate 5'-phosphatase ・ Thymidylate kinase ・ Thymidylate synthase ・ Thymidylate synthase (FAD) ・ Thymidylate synthase inhibitor ・ Thymine ・ Thymine dioxygenase ・ Thymine glycol ・ Thymine-DNA glycosylase ・ Thymineless death ・ Thymio ・ Thymioptila ・ Thymios Karakatsanis ・ Thymios Vlachavas ・ Thymistadopsis ・ Thymistadopsis albidescens ・ Thymistadopsis trilinearia ・ Thymistadopsis undulifera ・ Thymistida ・ Thymistida nigritincta ・ Thymistida tripunctata ・ Thymistida undilineata ・ Thymme Jones ・ Thymocyte Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Thymineless death ： ウィキペディア英語版 Thymineless death Thymineless death is the phenomenon by which bacteria, yeasts and mammalian cells undergo irreversible cell death when they are starved of thymidine triphosphate (dTTP), an essential precursor for DNA replication. This phenomenon underlies the mechanism of action of several antibacterial, antimalarial and anticancer agents, such as Trimethoprim, Sulfamethoxazole, Methotrexate and Fluorouracil.〔 == History == The phenomenon was first reported in 1954 by Hazel D. Barner and Seymour S. Cohen in ''Escherichia coli'' when thymine requiring mutants of the bacterium lost viability when grown in a medium lacking thymine but containing other essential nutrients.〔(50 years ago in cell biology - A virologist recalls his work on cell growth inhibition )〕 Subsequently, this discovery led to the development of or explained the mechanism of action of several pyrimidine analogs that targeted thymine metabolism in bacteria and tumor cells.〔 The phenomenon was commonly attributed to "unbalanced growth" wherein cells continued fundamental processes of RNA transcription, protein synthesis and metabolism in the absence of DNA replication. However, nutrient starvation generally do not kill cells to the extent as observed in cells that lack thymine. The molecular mechanism of thymineless death remains unknown;〔 DNA breaks were observed during thymineless death, which could explain the killing. Possible pathways involved with the killing mechanism include: replication initiation,〔 breakage of ongoing replication forks, futile DNA repair,〔 replication origin destruction, and an addiction module. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Thymineless death」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.